There’s a certain joy that fills the kitchen when the oven door opens to reveal a bubbling dish of Three-Cheese Meatball Mostaccioli, and the rich aroma of melted cheese invites everyone to gather around the table. As I prepared for a cozy family dinner last week, I craved a dish that would not only satisfy my hunger but also bring a sense of warmth and togetherness. This recipe, combining three types of cheese with hearty meatballs and tender mostaccioli, was the answer to that need.
Long gone are the days of uninspiring fast food meals; this easy-to-make recipe transforms simple ingredients into a delightful feast, perfect for sharing on a chilly evening or impressing guests at a potluck. With just a few basic steps, you can create a restaurant-quality dish right in the comfort of your home. Trust me, your taste buds will thank you after one delicious bite! Get ready to indulge in comforting flavors that are nostalgic yet refreshingly easy to prepare.
Why will you love Three-Cheese Meatball Mostaccioli?
Comforting and hearty: This dish combines three delicious cheeses with hearty meatballs and mostaccioli to create a warm and inviting meal that feels like a hug in a bowl.
Simplicity: With just a few steps, you’ll have a stunning dish ready to serve, which demystifies homemade cooking and keeps it accessible for everyone.
Crowd-pleaser: Perfect for gatherings, this recipe will have your friends and family raving over its cheesy goodness.
Customizable: Want to add veggies? Go for it! You can easily personalize this dish to suit your taste by mixing in your favorite ingredients.
Make-ahead friendly: Prep it in advance and pop it in the oven when you’re ready—saving time for everything else that matters!
Elevate your cooking with this delightful recipe that perfectly blends convenience and flavor, proving that you don’t need to sacrifice taste for ease.
Three-Cheese Meatball Mostaccioli Ingredients
For the Pasta
• Mostaccioli – 16 ounces of this pasta shape holds on to the cheese and sauce beautifully.
For the Cheese Mixture
• Ricotta cheese – 15 ounces of part-skim ricotta adds creaminess and depth.
• Eggs – 2 large, lightly beaten to help bind the mixture together.
• Grated Romano cheese – 1/2 cup contributes a sharp, tangy flavor.
• Shaved Parmesan cheese – 3/4 cup adds a rich, salty note that melts perfectly on top.
For the Meat Mixture
• Ground beef – 1 pound, providing a hearty, protein-packed base.
• Frozen Italian meatballs – 12 ounces, thawed and ready to complement the mostaccioli.
For Flavoring
• Onion – 1 medium, chopped, it adds a sweet and savory layer to the dish.
• Brown sugar – 1 tablespoon balances the acidity of the pasta sauce.
• Italian seasoning – 1 tablespoon for a burst of herbal flavor.
• Garlic powder – 1 teaspoon enhances the overall savory profile.
• Pepper – 1/4 teaspoon for a gentle kick of spice.
For the Sauce
• Pasta sauce with meat – 2 jars (24 ounces each), the delicious base for our cheesy layers.
Optional Garnish
• Fresh basil or oregano leaves – Torn fresh herbs add a pop of color and freshness right before serving.
Gather these ingredients to prepare your Three-Cheese Meatball Mostaccioli and be ready for a spectacular meal that everyone will love!
How to Make Three-Cheese Meatball Mostaccioli
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Preheat your oven to 350°F (175°C). This ensures your dish will bake evenly and reach that perfect bubbly goodness.
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Cook the mostaccioli according to the package directions; drain well. You want them al dente, as they’ll continue to cook in the oven.
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Brown the ground beef and chopped onion in a skillet over medium heat until the beef is no longer pink, about 5-7 minutes. Drain any excess fat to keep your dish light and flavorful.
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Combine the cooked mostaccioli, beef mixture, ricotta cheese, beaten eggs, brown sugar, Italian seasoning, garlic powder, pepper, and 1/4 cup of Romano cheese in a large bowl. Mix thoroughly to ensure every bite is packed with flavor!
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Spread a thin layer of pasta sauce on the bottom of a baking dish. This prevents sticking and adds moisture to the base of your dish.
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Pour half of the mostaccioli mixture into the dish, leveling it out. Top this layer with half of the thawed meatballs and half of the remaining pasta sauce, creating a delightful blend of flavors.
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Repeat the layers with the remaining mostaccioli mixture, meatballs, and pasta sauce. This layering makes each slice incredibly flavorful.
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Sprinkle the remaining Romano and shaved Parmesan cheeses on top. These will melt into a cheesy, golden crust as it bakes!
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Cover the dish with aluminum foil and bake for 30 minutes. This helps retain moisture and ensures everything heats through.
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Remove the foil and bake for an additional 15 minutes or until the cheese is bubbly and golden. The transformation will be stunning, and your kitchen will smell delightful!
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Let stand for 10 minutes before serving. This allows the layers to set and makes it easier to cut into portions. Garnish with fresh herbs if desired for a beautiful finish.
Optional: Add crushed red pepper flakes for a spicy kick!
Exact quantities are listed in the recipe card below.

Expert Tips for Three-Cheese Meatball Mostaccioli
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Perfect Pasta: Cook mostaccioli al dente since they will absorb sauce while baking, preventing a mushy texture in your dish.
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Flavor Layers: Don’t skip on the layers. Properly layering your meat and cheese mixtures ensures every bite is a delightful explosion of flavor.
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Moisture Control: Use a thin layer of pasta sauce at the bottom to prevent sticking while adding moisture—this keeps your mostaccioli from drying out.
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Cheese Blend: Mix Romano cheese into the pasta mixture for heightened flavor, while top cheeses should be a mix of Parmesan for a beautiful, golden crust.
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Rest Time: Allow the dish to sit before serving. Resting for 10 minutes after baking helps set the layers, making it easier to cut and serve.
Enjoy your homemade Three-Cheese Meatball Mostaccioli to its fullest potential with these helpful tips!
Make Ahead Options
These Three-Cheese Meatball Mostaccioli are perfect for meal prep enthusiasts! You can prepare the entire dish up to 24 hours in advance. Start by assembling the layers in your baking dish, then cover with aluminum foil and refrigerate. This method helps the flavors meld beautifully. When you’re ready to enjoy, simply remove it from the refrigerator and bake it at 350°F (175°C) for 45-50 minutes, adding an extra 10-15 minutes if you’re cooking it straight from the fridge. For optimal quality, be sure to keep it tightly covered to retain moisture. Your meal will be just as delicious, ready to impress without any last-minute fuss!
Three-Cheese Meatball Mostaccioli Variations
Customize your dish for even more delight by exploring these scrumptious variations!
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Vegetarian Option: Replace ground beef with sautéed mushrooms, zucchini, and spinach for a hearty and wholesome twist. The earthy flavors blend beautifully with the cheeses, making each bite a celebration of veggies.
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Spicy Kick: Add 1 teaspoon of crushed red pepper flakes to the pasta mixture for a flavorful zing. This adds just the right heat, awakening the dish with a vibrant boost that will leave your taste buds dancing.
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Creamy Spin: Stir in 1 cup of cream cheese with the ricotta for a creamier texture. The extra richness elevates the overall mouthfeel and takes the creaminess to new heights—perfect for cheese lovers!
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Herb Infusion: Incorporate fresh herbs like basil, parsley, or thyme directly into the mostaccioli mixture. This add-in brings a fresh garden quality that brightens the flavors, making every bite taste like summer.
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Lower-Carb Option: Swap the mostaccioli for spiralized zucchini or shirataki noodles. This delicious twist not only cuts down on carbs but also adds a unique texture that complements the meatballs beautifully.
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Cheese Lovers Delight: Experiment with different cheese combinations like mozzarella or cheddar for unique flavor profiles. Each cheese brings its specific flavor and melting quality, ensuring a delightful cheese experience in every bite!
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Nutty Flavor: Add a sprinkle of toasted pine nuts or walnuts on top before baking. This unexpected crunch offers a delightful contrast to the soft texture of the mostaccioli, making every mouthful interesting and satisfying.
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Stuffed Variation: Stuff manicotti shells with the three-cheese mixture instead of layering. This fun twist transforms your dish into a charming, personalized presentation that showcases your creativity in the kitchen!
What to Serve with Three-Cheese Meatball Mostaccioli?
A hearty dish like this invites a variety of delightful sides to create an unforgettable meal experience.
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Garlic Bread: The perfect companion, this warm, buttery treat soaks up any extra sauce and enhances the cozy Italian atmosphere.
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Caesar Salad: Crisp romaine with creamy dressing adds a refreshing crunch that balances the rich flavors of the mostaccioli. A sprinkling of Parmesan elevates it further!
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Steamed Broccoli: Bright green and nutrient-rich, steamed broccoli offers a mild flavor and vibrant color that contrasts beautifully against the pasta.
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Antipasto Platter: A selection of cured meats, olives, and cheeses complements the dish while inviting guests to nibble and socialize before the main course.
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Roasted Vegetables: Seasonal roasted veggies not only provide color but their caramelized sweetness adds a complex note, enhancing every bite of mostaccioli.
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Red Wine: A robust Chianti or Merlot pairs beautifully with the meat and cheese combination, making dinner feel like a special occasion.
Let your guests savor each element of this comforting feast as you revel in the deliciously warm atmosphere!
Storage Tips for Three-Cheese Meatball Mostaccioli
Room Temperature: Serve your Three-Cheese Meatball Mostaccioli warm and fresh, but if leftovers remain, they should not sit out for more than 2 hours to ensure food safety.
Fridge: Store leftovers in an airtight container in the fridge for up to 3 days. Reheat portions in the microwave or oven until warmed through.
Freezer: You can freeze unbaked or baked mostaccioli for up to 3 months. For best results, wrap it tightly in plastic wrap and then foil, or use a freezer-safe container.
Reheating: When ready to enjoy, reheat from frozen in the oven at 350°F (175°C) for about 1 hour, or until piping hot. If refrigerated, about 20-30 minutes should suffice.

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Three-Cheese Meatball Mostaccioli Recipe FAQs
What type of mostaccioli should I use?
Absolutely! For the best results, look for a high-quality, sturdy brand of mostaccioli that can hold onto the sauce and cheese well. It’s the perfect bite when cooked al dente.
How should I store leftover Three-Cheese Meatball Mostaccioli?
Simply transfer any leftovers into an airtight container and store them in the fridge. They’ll stay fresh for up to 3 days. Reheating is easy; just pop it in the microwave or oven until it’s warmed through!
Can I freeze Three-Cheese Meatball Mostaccioli?
Yes! For freezing, you can wrap the unbaked or baked mostaccioli tightly in plastic wrap followed by aluminum foil to prevent freezer burn. This dish will keep in the freezer for up to 3 months. When you’re ready to enjoy, just reheat from frozen at 350°F (175°C) for about an hour.
How can I prevent my mostaccioli from becoming mushy?
Good question! To maintain a perfect texture, always cook the mostaccioli al dente according to package instructions. They will continue to absorb sauce while baking, so this helps to avoid a mushy end result.
Are there any dietary considerations with this recipe?
Always good to check! This dish contains gluten from the pasta and dairy from the cheese, making it unsuitable for those with gluten or dairy allergies. For a gluten-free option, you can substitute mostaccioli with a gluten-free pasta variety.

Ultimate Three-Cheese Meatball Mostaccioli You’ll Crave
Ingredients
Equipment
Method
- Preheat your oven to 350°F (175°C).
- Cook the mostaccioli according to the package directions; drain well.
- Brown the ground beef and chopped onion in a skillet over medium heat until the beef is no longer pink, about 5-7 minutes.
- Combine the cooked mostaccioli, beef mixture, ricotta cheese, beaten eggs, brown sugar, Italian seasoning, garlic powder, pepper, and 1/4 cup of Romano cheese in a large bowl.
- Spread a thin layer of pasta sauce on the bottom of a baking dish.
- Pour half of the mostaccioli mixture into the dish, level it out. Top this layer with half of the thawed meatballs and half of the remaining pasta sauce.
- Repeat the layers with the remaining mostaccioli mixture, meatballs, and pasta sauce.
- Sprinkle the remaining Romano and shaved Parmesan cheeses on top.
- Cover the dish with aluminum foil and bake for 30 minutes.
- Remove the foil and bake for an additional 15 minutes or until the cheese is bubbly and golden.
- Let stand for 10 minutes before serving.







